Osteopontin: Role in extracellular matrix deposition and myocardial remodeling post-MI

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• 作者：Mahipal Singh ; Cerrone R. Foster ; Suman Dalal ; Krishna Singh
• 关键词：Osteopontin ; ECM ; MMPs ; Myocardial infarction ; Myocardial remodeling
• 刊名：Journal of Molecular and Cellular Cardiology
• 出版年：2010
• 出版时间：March 2010
• 年：2010
• 卷：48
• 期：3
• 页码：538-543
• 全文大小：570 K

文摘

Remodeling after myocardial infarction (MI) associates with left ventricular (LV) dilation, decreased cardiac function and increased mortality. The dynamic synthesis and breakdown of extracellular matrix (ECM) proteins play a significant role in myocardial remodeling post-MI. Expression of osteopontin (OPN) increases in the heart post-MI. Evidence has been provided that lack of OPN induces LV dilation which associates with decreased collagen synthesis and deposition. Inhibition of matrix metalloproteinases, key players in ECM remodeling process post-MI, increased ECM deposition (fibrosis) and improved LV function in mice lacking OPN after MI. This review summarizes — 1) signaling pathways leading to increased expression of OPN in the heart; 2) the alterations in the structure and function of the heart post-MI in mice lacking OPN; and 3) mechanisms involved in OPN-mediated ECM remodeling post-MI.