Abstract # 1830 Inflammation and circulating LPS are independent predictors of depressive symptoms and fatigue in stable kidney transplant recipients

详细信息    查看全文

• 作者：J.A. Bosch^a ; ^b ; W. Chan^b ; ^d ; P.G. McTernan^c ; O. Kaur^d ; A.C. Phillips^b ; R. Borrows^d
• 刊名：Brain, Behavior, and Immunity
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：57
• 期：supp_S
• 页码：e34-e35
• 全文大小：47 K

文摘

Over 40% of kidney transplant recipients (KTRs) report severe fatigue and 25% show evidence of clinical depression. These symptoms may in part result from persistent inflammation, in which translocation of gut lipopolysaccharide (LPS) could be a contributing factor. The present study investigated if plasma LPS predicted systemic inflammation, as well as symptoms of depression and fatigue. This study enrolled 128 stable KTRs that were >24 months post-transplantation [Mean age = 50 SD ± 15; 56% male]. Symptoms of depression and fatigue were assessed using the Hospital Anxiety and Depression scale and the Multidimensional Fatigue Inventory. Fasting blood was analysed for LPS and C-reactive protein (hsCRP). Analyses were adjusted for clinical and demographic markers, including age, ethnicity, gender, BMI, and kidney function (eGFR). As expected, LPS levels predicted hsCRP (β$\beta$ = .39, p < .001). In turn, both LPS and hsCRP predicted depressive symptoms (β$\beta$ = .31 and beta = .24, respectively, p < .01), as well as several dimensions of fatigue (β$\beta$s > .17 and <.31, p < .01). After adjustment for inflammation, LPS remained an independent predictor of depressive symptoms (β$\beta$ = .28, p<$<$.01) as well as fatigue (‘general fatigue’, ‘physical fatigue’, ‘reduced motivation’, and ‘mental fatigue’ (β$\beta$s > .19 and <29, p < .05 and >.001). In conclusion, this study identified inflammation and circulating endotoxin as independent predictors of depressive symptoms and fatigue. Control of circulating LPS, e.g., through manipulation of gut permeability, may help to improve mood and reduce lethargy in KTRs.