Synthesis, antiproliferative and anti-dengue virus evaluations of 2-aroyl-3-arylquinoline derivatives
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- 作者：Chih-Hua Tsenga ; chihhua@kmu.edu.tw" class="auth_mail ; Chun-Kuang Linb ; Yeh-Long Chenc ; Chih-Yao Hsuc ; Huey-Nan Wud ; Chin-Kai Tsenge ; f ; Jin-Ching Leeg ; jclee@kmu.edu.tw" class="auth_mail
- 关键词：2-Aroyl-3-arylquinoline ; Ribavirin ; Topotecan ; Anti-dengue virus ; Antiproliferative
- 刊名：European Journal of Medicinal Chemistry
- 出版年：22 May 2014
- 年：2014
- 卷：79
- 期：Complete
- 页码：66-76
- 全文大小：1180 K
文摘
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A series of 2-aroyl-3-arylquinoline derivatives were synthesized.
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13a and 17 inhibit the DENV2 RNA expression with potency approximately equal to that of ribavirin.
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Compounds 19a–19c showed potent cytotoxicity as that of topotecan.