Fatty acid induced metabolic memory involves alterations in renal histone H3K36me2 and H3K27me3
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- 作者：Sandeep Kumar sandyjan87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Himani Pamulapati Pamulapatihimani@drreddys.com" class="auth_mail" title="E-mail the corresponding author ; Kulbhushan Tikoo ; tikoo.k@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Metabolic memory ; Type 2 diabetes ; Epigenetics ; Diabetic nephropathy
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：422
- 期：Complete
- 页码：233-242
- 全文大小：1940 K
文摘
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Metabolic memory (MM) by palmitate/HFD is associated with increased FOXO1 activity.
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MM by palmitate/HFD involves alteration in histone H3K36me2 on FOXO1 promoter.
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We show decreased abundance of histone H3K27me3 on FOXO1 promoter, in the kidneys of HFD fed rats.
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This decrease in histone H3K27me3 on FOXO1 promoter was persistent even after diet reversal.