Regulation of MDA-MB-231 cell proliferation by GSK-3尾 involves epigenetic modifications under high glucose conditions
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- 作者：Chanchal Gupta ; Jasmine Kaur ; Kulbhushan Tikoo ; tikoo.k@gmail.com" class="auth_mail
- 关键词：ChIP-qPCR ; Chromatin immunoprecipitation-quantitative polymerase chain reaction ; Co-IP ; Co-immunoprecipitation ; GSK-3尾 ; Glycogen synthase 3 beta ; MMP-7 ; Matrix metalloproteinase 7
- 刊名：Experimental Cell Research
- 出版年：15 May 2014
- 年：2014
- 卷：324
- 期：1
- 页码：75-83
- 全文大小：1493 K
文摘
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High glucose induces phosphorylation of histone H3 and dephosphorylation of GSK-3尾.
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Moreover, hyperglycemia also leads to increased DNA methylation in MDA-MB-231 cells.
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Inhibition of GSK-3尾 prevented histone H3 phosphorylation and reduced DNMT1 levels.
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Interplay exists between GSK-3尾, histone H3 phosphorylation and DNA methylation.