Volatile organic compounds in plasma for the diagnosis of esophageal adenocarcinoma: a pilot study

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• 作者：Amit Bhatt ; MD¹ ; ; Mansour A. Parsi ; MD ; MPH¹ ; Tyler Stevens ; MD¹ ; Scott Gabbard ; MD¹ ; Arthi Kumaravel ; MD¹ ; Sunguk Jang ; MD¹ ; David Grove ; PhD² ; Rocio Lopez ; MS³ ; Sudish Murthy ; MD⁴ ; John J. Vargo ; MD ; MPH¹ ; Raed Dweik ; MD²
• 关键词：BE ; Barrett&rsquo ; s esophagus ; AUC ; area under the curve ; EAC ; esophageal adenocarcinoma ; VOC ; volatile organic compound
• 刊名：Gastrointestinal Endoscopy
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：84
• 期：4
• 页码：597-603
• 全文大小：1036 K

文摘

A noninvasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for the diagnosis of EAC has not been previously studied.

Methods

Plasma samples were collected from subjects with EAC and GERD before endoscopy. Twenty-two preselected VOCs were analyzed with selected ion flow tube mass spectrometry.

Results

The headspaces from 39 plasma samples (20 EAC, 19 GERD) were analyzed. The levels of 9 VOCs (acetonitrile, acrylonitrile, carbon disulfide, isoprene, 1-heptene, 3-methylhexane, [E]-2-nonene, hydrogen sulfide, and triethylamine) were significantly altered in EAC patients compared with GERD patients. A multivariable logistic regression analysis was performed to build a model for the prediction of EAC. The model identified patients with EAC with an area under the curve of 0.83 (95% confidence interval, 0.67-0.98).

Conclusions

Plasma VOCs may be useful in diagnosing EAC. Larger studies are needed to confirm our pilot study observations.