Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK

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• 作者：Masakazu Kono ; Koichiro Tatsumi ; Alberto M. Imai ; Kengo Saito ; Takayuki Kuriyama ; Hiroshi Shirasawa
• 关键词：Coronavirus ; 229E ; Chloroquine ; p38 ; MAPK ; ERK
• 刊名：Antiviral Research
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：77
• 期：2
• 页码：150-152
• 全文大小：227 K

文摘

The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, L132 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.