• 作者：Fang-Fei Wei^a ; Nadja E.A. Drummen^b ; Aletta E. Schutte^c ; ^d ; Lutgarde Thijs^a ; Lotte Jacobs^a ; Thibaut Petit^a ; Wen-Yi Yang^a ; Wayne Smith^c ; Zhen-Yu Zhang^a ; Yu-Mei Gu^a ; Tatiana Kuznetsova^a ; Peter Verhamme^e ; Karel Allegaert^f ; Rudolph Schutte^c ; ^d ; Evelyne Lerut^g ; Pieter Evenepoel^h ; Cees Vermeer^b ; Jan A. Staessen^a ; ^b ; ^{jan.staessen@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; ^{ja.staessen@maastrichtuniversity.nl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chronic kidney disease ; Glomerular filtration rate ; Matrix Gla protein ; Population science ; Vitamin K
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：4
• 期：Complete
• 页码：162-169
• 全文大小：481 K

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In Flemish, eGFR was inversely associated with dp-ucMGP and positively with t-ucMGP.

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In Flemish, the risk of chronic kidney disease increased with higher dp-ucMGP.

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We confirmed the inverse association of eGFR with dp-ucMGP in black South Africans.

In a multi-ethnic population study, we assessed the association of renal glomerular filtration, a microvascular trait, with circulating matrix Gla protein (MGP). In white Flemish and in South African blacks, glomerular filtration decreased and the risk of chronic kidney disease increased with higher levels of inactive desphospho-uncarboxylated MGP. Our findings support the notion that following vitamin-K dependent carboxylation active MGP not only inhibits calcification of large arteries, as was known before, but also protects the renal microcirculation. Future studies might test whether vitamin K supplementation promotes renal health in the general population.