Combined therapeutic potential of nuclear receptors with receptor tyrosine kinase inhibitors in lung cancer
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- 作者：Peninah M. Wairagua ; b ; c ; Kwang Hwa Parkd ; Jihye Kima ; b ; c ; Jong-Whan Choia ; Hyun-Won Kima ; Byung-Il Yeha ; Soon-Hee Jungd ; Suk-Joong Yonge ; Yangsik Jeonga ; b ; c ; yjeong@yonsei.ac.kr" class="auth_mail
- 关键词：Combinational therapy ; PPAR纬 ; LXR ; Lung cancer ; Tyrosine kinase inhibitors
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：9 May 2014
- 年：2014
- 卷：447
- 期：3
- 页码：490-495
- 全文大小：776 K
文摘
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The 48 NR genes and 48 biological anti-cancer targets are profiled in paired-cells.
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Growth inhibition by NR ligands or TKIs is target receptor level-dependent.
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T0901317 with gefitinib/PHA665752 shows additive growth inhibition in lung cells.