An international field study of the EORTC QLQ-PR25: A questionnaire for assessing the health-related quality of life of patients with prostate cancer

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• 作者：George van Andel ; Andrew Bottomley ; Sophie D. Fosså ; Fabio Efficace ; Corneel Coens ; Stephane Guerif ; Howard Kynaston ; Paolo Gontero ; George Thalmann ; Atif Akdas ; Sven D’ ; Haese ; Neil K. Aaro
• 关键词：Prostate cancer ; Quality of life ; Patient-reported outcome ; Questionnaire ; Bladder function ; Urinary function ; Sexuality
• 刊名：European Journal of Cancer
• 出版年：2008
• 出版时间：November 2008
• 年：2008
• 卷：44
• 期：16
• 页码：2418-2424
• 全文大小：126 K

文摘

Aim

To evaluate the psychometrics of the EORTC QLQ-PR25, a questionnaire assessing the health-related quality of life of prostate cancer patients.

Methods

The QLQ-PR25 and the QLQ-C30 were administered to 642 prostate cancer patients from 13 countries treated with curative or palliative intent. The QLQ-PR25 assesses urinary, bowel and sexual symptoms and functioning, and the side-effects of hormonal treatment.

Results

Five hundred and nine patients were available for the final analysis. Multitrait scaling analyses confirmed the hypothesised scale structure of the QLQ-PR25. Internal consistency reliability was good (coefficient α = 0.70–0.86) for the urinary symptoms and sexual function scales, but lower for the bowel function and side-effects of hormonal treatment scales (α < 0.70). The module discriminated clearly between clinically distinct patient subgroups, and was responsive to changes in health status over time.

Conclusion

In general, the QLQ-PR25 demonstrates acceptable psychometric properties and clinical validity. Some caution should be used in interpreting the bowel function and side-effects of hormonal therapy scales; results can be reported at the individual item and scale level.