A novel metallo-¦Â-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem

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• 作者：Norifumi Shigemoto^a ; ^b ; ^c ; Shizuo Kayama^a ; ^b ; Ryuichi Kuwahara^a ; ^b ; ^d ; Junzo Hisatsune^a ; ^b ; Fuminori Kato^a ; ^b ; Hisaaki Nishio^e ; Katsutoshi Yamasaki^f ; Yasunao Wada^g ; Taijiro Sueda^c ; Hiroki Ohge^a ; ^h ; Motoyuki Sugai^a ; ^b ; ^{sugai@hiroshima-u.ac.jp}
• 关键词：metallo-¦Â-lactamase ; Klebsiella ; resistance ; blaIMP-34
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：76
• 期：1
• 页码：119-121
• 全文大小：232 K

文摘

We investigated 5 metallo-¦Â-lactamase (MBL)-positive Klebsiella isolates from Japan showing intermediate resistance to imipenem. Sequencing of the MBL gene identified a novel variant of IMP-1 with a single amino acid substitution, Glu87Gly. This variant is designated as IMP-34 where bla_IMP-34 is located on a transmissible plasmid.