Synthesis of some novel indeno[1,2-b]quinoxalin spiro-β-lactam conjugates

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• 作者：Javad Ameri Rad^a ; Aliasghar Jarrahpour^a ; ^{jarrah@susc.ac.ir} ; Cem Cü ; neyt Ersanlı^b ; Zeliha Atioğlu^c ; Mehmet Akkurt^d ; Edward Turos^e
• 关键词：indeno[1 ; 2-b]quinoxalin ; Staudinger reaction ; β-lactams ; Spiro
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：23 February 2017
• 年：2017
• 卷：73
• 期：8
• 页码：1135-1142
• 全文大小：1484 K
• 卷排序：73

文摘

This article reports the synthesis of some new spiro-β-lactams bearing an indeno[1,2-b]quinoxaline ring system, prepared by a [2 + 2] cycloaddition of ketenes with imines derived from 11-H-indeno[1,2-b]quinoxalin-11-one. The structures of newly synthesized spiro-β-lactams 2a–i and 3a-i were characterized by FT-IR, 1H NMR, 13C NMR, mass spectrometry and elemental analyses. The relative stereochemistry of spiro-β-lactams 2a and 3a was determined unequivocally by X-ray crystallographic studies.