Muropeptide signature of inhibitors of protein synthesis correlates with β-lactam synergism against methicillin-resistant Staphylococcus aureus

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• 作者：Bertrand Guignard^a ; ^b ; ^{Bertrand.Guignard@hcuge.ch} ; Paul A. Majcherczyk^a ; Cé ; dric Monachon^a ; Jacques Vouillamoz^a ; Philippe Moreillon^a
• 关键词：β-Lactams ; Protein synthesis inhibitors ; Muropeptide ; Methicillin-resistant Staphylococcus aureus ; Quinupristin/dalfopristin ; Synergism
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：1
• 页码：53-61
• 全文大小：856 K
• 卷排序：49

文摘

Quinupristin/dalfopristin (Q/D) and β-lactams interact positively against MRSA. Protein inhibitors produce a muropeptide signature in Staphylococcus aureus that correlates with their synergism with β-lactams. Antibacterial agents with other mechanisms of action do not produce these anomalies and do not synergise with β-lactams. A decrease in PBP2 expression by protein synthesis inhibitors would provide a rationale for this synergism against MRSA.