MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB
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- 作者：Jonathan Shintaku1 ; 2 ; 3 ; Jennifer M. Peterson1 ; 2 ; Erin E. Talbert1 ; 2 ; Jin-Mo Gu1 ; 2 ; 3 ; Katherine J. Ladner1 ; 2 ; Dustin R. Williams1 ; 2 ; Kambiz Mousavi4 ; Ruoning Wang5 ; Vittorio Sartorelli4 ; Denis C. Guttridge1 ; 2 ; 6 ; denis.guttridge@osumc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：mitochondrial biogenesis ; oxidative metabolism ; skeletal muscle ; MyoD ; NF-kappaB ; RelB ; ppargc1b ; PGC-1beta
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：514-526
- 全文大小：3313 K
文摘
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MyoD regulates the oxidative metabolic capacity of adult skeletal muscle
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ChIP-seq analysis identified MyoD binding on the PGC-1β, but not PGC-1α, gene locus
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MyoD cooperates with alternative NF-κB to regulate PGC-1β transcription
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MyoD and RelB co-occupy many other genes involved in aerobic respiration