Retesting of HPV-negative cancers tested with SPF10/DEIA shows only 2.1% (55/2635) false negative results. DNA of cutaneous HPVs within AlphaHPVs and BetaHPVs was found in a very low proportion of mucosal cancer samples (0.23%; 6/2635), The contribution to malignancy of cutaneous HPVs need to be elucidated although it remains minor.