Effect of immobilization, off-loading and zoledronic acid on bone mineral density in patients with acute Charcot neuroarthropathy: A prospective randomized trial

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• 作者：Toni-Karri Pakarinen ; MD^a ; ^{tkpakarinen@me.com} ; Heikki-Jussi Laine ; MD PhD^a ; Heikki Mä ; enpä ; ä ; MD PhD^a ; ^e ; Mika Kä ; hö ; nen ; MD PhD^c ; ^e ; Pentti Mattila ; MD^d ; Jorma Lahtela ; MD PhD^b ; ^e
• 关键词：BMD ; bone mineral density ; CNA ; Charcot neuroarthropathy ; DEXA ; dual X-ray absorptiometry
• 刊名：Foot and Ankle Surgery
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：19
• 期：2
• 页码：121-124
• 全文大小：276 K

文摘

Backround

Bisphosphonates are commonly used as an adjuvant in the management of acute Charcot neuroarthropathy (CNA), although the clinical efficacy of the treatment is controversial. The aim of the present study is to investigate the effect of immobilization and zoledronic acid on bone mineral density (BMD) changes during the treatment of acute CNA.

Methods

Thirty-five patients with acute midfoot CNA were randomly assigned to treatment with either zolendronic acid or placebo. BMD of the lumbar spine and both hips was measured at baseline and after six months of treatment.

Results

Comparison between BMD at presentation and at 6 months demonstrated a significant fall in BMD in the placebo group at the CNA-affected femoral neck (?3.2 % , p = 0.016) and in the CNA-free hip (?1.2 % , p = 0.026). Conversely, a significant rise in BMD was observed in the zolendronic acid group at all measured areas of the CNA-free hip.

Discussion and conclusions

Immobilization and off-loading does not lead to marked disuse osteoporosis in patients with acute CNA after 6 months of treatment. Treatment with zoledronic acid led to a statistically significant increase in hip BMD compared to placebo.