Ugi three-component coupling reaction for the synthesis of 2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazocin-5(6H)-yl)-2-phenylacetamide derivatives
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- 作者：P. Lakshmi Reddy ; D. Ashok Kumar ; M. Lakshmi Devi ; T. Veera Reddy ; B.V. Subba Reddy ; R. Narender
- 关键词：Claisen&ndash ; Schmidt reaction ; Paal&ndash ; Knorr reaction ; Ugi 4C-3CC reaction ; Benzo[b]pyrrolodiazocinyl derivatives
- 刊名：Tetrahedron Letters
- 出版年：15 January, 2014
- 年：2014
- 卷：55
- 期：3
- 页码：657-661
- 全文大小：5150 K
文摘
A three-component, four center Ugi reaction of 3-(1-(2-aminophenyl)-5-phenyl-1H-pyrrol-2-yl)propanoic acid with aromatic aldehyde and t-butyl isocyanide has been achieved to produce a novel class of N-tert-butyl-2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazacine-5(6H)-yl)-2-phenylacetamides in moderate to good yields.