Recurrent endometrioma and ovarian reserve: biological connection or surgical paradox?

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• 作者：Edgardo Somigliana ; Laura Benaglia ; Paolo Vercellini ; Alessio Paffoni ; Guido Ragni ; Luigi Fedele
• 关键词：endometrioma ; in vitro fertilization ; ovulation ; recurrence
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：204
• 期：6
• 页码：529.e1-529.e5
• 全文大小：254 K

文摘

Objective

Cumulative evidence supports the view that ovarian endometriomas originate from ovulatory events and that the ovarian reserve is reduced following surgery. On these bases, we have hypothesized that the risk of recurrence may be related to the residual ovarian reserve of the operated ovary.

Study Design

We retrospectively selected 45 women scheduled for in vitro fertilization who previously underwent surgical excision of monolateral endometriomas and compared ovarian responsiveness in those who did (n = 24) and did not (n = 21) have a recurrent endometrioma.

Results

In the intact ovaries, the mean ± SD number of codominant follicles in women with and without recurrences was 3.5 ± 1.7 and 3.7 ± 2.2, respectively (P = NS). In the affected ovaries, the mean ± SD number of follicles in gonads with and without recurrences was 2.5 ± 2.3 and 1.1 ± 1.5, respectively (P < .05).

Conclusion

Ovarian responsiveness is higher in gonads that developed recurrent endometriomas.