microRNAs in the pathophysiology of CKD-MBD: Biomarkers and innovative drugs

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• 作者：Valé ; rie Metzinger-Le Meuth^a ; ^b ; Sté ; phane Burtey^c ; Pierre Maitrias^a ; ^d ; Ziad A. Massy^e ; Laurent Metzinger^a ; ^{laurent.metzinger@u-picardie.fr}
• 关键词：microRNA ; Bone ; Vascular disease ; CKD ; Gene therapy ; Biomarker
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：337-345
• 全文大小：1413 K
• 卷排序：1863

文摘

miRNAs are deregulated in patients suffering from CKD-MBD. miR-126 is a potential biomarker of endothelial dysfunction in CKD. miR-155 and miR-223 are implicated in both vascular calcification and osteoporosis. miRNAs are potential innovative drugs in the CKD-MBD context.