Mineral intake independent from gastric irritation or pica by cell-dehydrated rats

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• 作者：Juliana Constancio^a ; Daniela T.B. Pereira-Derderian^a ; José ; V. Menani^a ; Laurival A. De Luca Jr. ;   ; ^a ;   ; ^{lucajr@foar.unesp.br}
• 关键词：Dehydration ; Thirst ; Sodium appetite ; Mineral lick ; Self-medication ; Gastric mucosa
• 刊名：Physiology and Behavior
• 出版年：2011
• 出版时间：24 October 2011
• 年：2011
• 卷：104
• 期：5
• 页码：659-665
• 全文大小：326 K

文摘

Gavage of 2 M NaCl (IG 2 M NaCl), a procedure to induce cell-dehydration¡ªand water and 0.15 M NaCl intake in a two-bottle choice test¡ªis also a potential gastric irritant. In this study, we assessed whether mineral intake induced by IG 2 M NaCl is associated with gastric irritation or production of pica in the rat. We first determined the amount of mineral solution (0.15 M NaCl, 0.15 M NaHCO₃, 0.01 M KCl and 0.05 mM CaCl₂) and water ingested in response to IG 2 M NaCl in a five-bottle test. Then, we used mineral solutions (0.01 M KCl and 0.15 M NaHCO₃), whose intakes were significantly increased compared to controls, and water in three-bottle tests to test the gastric irritation hypothesis. The IG 2 M NaCl induced KCl and NaHCO₃ intake that was not inhibited by gavage with gastric protectors Al(OH)₃ or NaHCO₃. IG 2 M NaCl or gavage of 0.6 N acetic acid induced mild irritation, hyperemia, of the glandular part of the stomach. A gavage of 50 % ethanol induced strong irritation seen as pinpoint ulcerations. Neither ethanol nor acetic acid induced any fluid intake. Neither IG 2 M NaCl nor acetic acid induced kaolin intake, a marker of pica in laboratory rats. Ethanol did induce kaolin intake. These results suggest that IG 2 M NaCl induced a mineral fluid intake not selective for sodium and independent from gastric irritation or pica.