Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions
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- 作者：Rotem Rubinstein1 ; 2 ; 7 ; Chan Aye Thu1 ; 7 ; Kerry Marie Goodman1 ; 7 ; Holly Noelle Wolcott1 ; 7 ; Fabiana Bahna1 ; 5 ; Seetha Mannepalli1 ; Goran Ahlsen2 ; 5 ; Maxime Chevee1 ; Adnan Halim6 ; Henrik Clausen6 ; Tom Maniatis1 ; Lawrence Shapiro1 ; 2 ; lss8@columbia.edu" class="auth_mail" title="E-mail the corresponding author ; Barry Honig1 ; 2 ; 3 ; 4 ; 5 ; bh6@columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2015
- 出版时间：22 October 2015
- 年：2015
- 卷：163
- 期：3
- 页码：629-642
- 全文大小：5502 K
文摘
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Crystal structures of EC1–EC3 regions of Pcdh-α, -β, and -γ isoforms are determined
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Pcdh homophilic specificity is mediated by a canonical EC1–EC4 domain interface
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Pcdhs dimerize in cis through the EC6 domain independent of their trans interactions
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Isoform-mismatch chain-termination mechanism to distinguish self from non-self