Molecular characterization of a bactericidal permeability-increasing protein/lipopolysaccharide-binding protein from black rockfish (Sebastes schlegelii): Deciphering its putative antibacterial role
Homolog of BPI/LBP was identified from black rockfish (RfBPI/LBP). Rf RfBPI/LBP resembled typical domain architecture of its homologues. Recombinant RfBPI/LBP showed selective antibacterial and LPS binding activity. RfBPI/LBP was ubiquitously expressed in tissues under physiological conditions. Transcriptional level of RfBPI/LBP was modulated under pathogenic stress.