Efficacy of a single dose hepatitis B depot vaccine

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• 作者：Lisa D. MacDonald ; Antar Fuentes-Ortega ; Leeladhar Sammatur ; Marc Mansour
• 关键词：Hepatitis B vaccine ; Single dose ; Liposomes
• 刊名：Vaccine
• 出版年：2010
• 出版时间：18 October 2010
• 年：2010
• 卷：28
• 期：44
• 页码：7143-7145
• 全文大小：185 K

文摘

A single dose formulation of a novel hepatitis B vaccine, consisting of an adjuvant emulsion of liposomes in oil was produced at a manufacturing scale and delivered to rabbits. This single dose vaccine generated a significantly higher antibody response than two doses of an alum-adjuvanted control vaccine in the short term, and was as effective as three doses of the control vaccine in the long term.