Synthesis, antifungal activity and docking study of 2-amino-4H-benzochromene-3-carbonitrile derivatives
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- 作者：BiBi Fatemeh Mirjalilia ; Leila Zamanib ; L.Zamani2008@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kamiar Zomorodianc ; Soghra Khabnadidehb ; Zahra Haghighijood ; Zahra Malakotikhaha ; Seyyed Amin Ayatollahi Mousavie ; Shaghayegh Khojastehe
- 关键词：2-Amino-4H-benzochromenes ; Nano-TiCl4.SiO2 ; Docking study ; Synthesis ; Antifungal ; Antibacterial
- 刊名：Journal of Molecular Structure
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1116
- 期：Complete
- 页码：102-108
- 全文大小：875 K
文摘
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A series of novel 2-amino-4H-benzochromene-3-carbonitrile derivatives in the presence of nano-TiCl4.SiO2 were synthesized.
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Some of the compounds showed good fungi static and fungicidal activity against some species of Candida.
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Docking simulation was performed to insert compounds in to CYP51 active site to determine the probable binding model.