Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice
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- 作者：Rick van der Geesta ; r.van.der.geest@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author ; Amber B. Ouweneela ; a.b.ouweneel@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author ; Ronald J. van der Sluisa ; r.vandersluis@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author ; Albert K. Groenb ; a.k.groen@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Miranda Van Ecka ; m.eck@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author ; Menno Hoekstraa ; hoekstra@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABCB4 ; ATP-binding cassette transporter B4 ; ADX ; adrenalectomy ; ALT/GPT ; alanine transaminase/glutamic pyruvic transaminase ; ANIT ; alpha-naphthylisothiocyanate ; APOA4 ; apolipoprotein A4 ; BSEP/ABCB11 ; bile salt efflux pump ; CYP7A1 ; cholesterol 7alpha-hydroxylase ; FXR/BAR ; farnesoid X receptor/bile acid receptor ; HDL ; high-density lipoprotein ; HMGCR ; HMG-CoA reductase ; LDL ; low-density lipoprotein ; LDLR ; low-density lipoprotein receptor ; NTCP1/SLC10A1 ; sodium/bile acid cotransporter member 1 ; PEPC
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：306
- 期：Complete
- 页码：1-7
- 全文大小：1027 K
文摘
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Cholestasis is associated with increased plasma glucocorticoid levels in mice.
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Adrenalectomy lowers cholestasis-associated liver injury and hypercholesterolemia.
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GR antagonist RU-486 similarly improves the cholestasis phenotype.
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Endogenous glucocorticoids promote re-uptake of circulating bile acids into liver.