Granuloma formation in leishmaniasis: A mathematical model
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- 作者：Nourridine Siewe ; sienourridine@gmail.com ; Abdul-Aziz Yakubu ; Abhay R Satoskar ; Avner Friedman
- 关键词：Granuloma ; Visceral leishmaniasis ; Mathematical model ; Immunesystem ; Sodium antimony gluconate ; Treatment ; Drug efficacy
- 刊名：Journal of Theoretical Biology
- 出版年：2017
- 出版时间：7 January 2017
- 年：2017
- 卷：412
- 期：Complete
- 页码：48-60
- 全文大小：1387 K
- 卷排序：412
文摘
As the parameter that gauges the strength of the immune response, β, increases, the proportion of Leishmania parasites to macrophages decreases. For humans with normal healthy immune system, the parameter β varies in the range 31<β<6231<β<62; for any β in this range, infected humans will die if untreated, but will recover if treated. The efficacy of a drug (such as SAG) decreases as β increases in the range 10<β<14010<β<140. However, SAG may have negative side-effects such as nausea, vomiting, diarrhea, dizziness and anaphylaxis which leads to low blood pressure and may cause death. Hence, there is a need to weigh the benefits of increasing the amount of drug (above the MTD) versus the possibility of life threatening side-effects.