Combined oral contraceptive use is associated with both improvement and worsening of mood in the different phases of the treatment cycle—A double-blind, placebo-controlled randomized trial

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• 作者：Cecilia Lundin^a ; Kristina Gemzell Danielsson^b ; Marie Bixo^c ; Lena Moby^a ; Hanna Bengtsdotter^d ; Izabella Jawad^d ; Lena Marions^e ; Jan Brynhildsen^f ; Agota Malmborg^f ; Ingela Lindh^g ; Inger Sundstr&ouml ; m Poromaa^a ; ^{inger.sundstrom@kbh.uu.se}
• 关键词：Randomized clinical trial ; Combined oral contraceptives ; Estrogen ; Progestagen ; Depression ; Anxiety ; Irritability
• 刊名：Psychoneuroendocrinology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：135-143
• 全文大小：1211 K
• 卷排序：76

文摘

Combined oral contraceptive is associated with small increases in anxiety, irritability, and mood swings during the intermenstrual phase. The adverse mood symptoms were most pronounced in the subgroup of women who reported previous side effects. A significant premenstrual improvement in depression was noted. The proportion of women who reported significant deterioration did not differ between treatments.