Active leptospermum honey (ALH) (medical-grade manuka honey) safety has been proven to be nontoxic, even in infants and children.

ALH bioactivities include preventing biofilm formation, painless autolytic debridement, anti-inflammatory, and antioxidant properties.

ALH antimicrobial properties have been shown to be effective against various bacteria.

ALH is unlikely to develop resistance.

ALH can be used through the entire cycle of wound healing.