CysLT₁R downregulation reverses intracerebroventricular streptozotocin-induced memory impairment via modulation of neuroinflammation in mice

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• 作者：Arijit Ghosh^a ; ¹ ; ² ; Fang Chen^a ; ¹ ; Feng Wu^b ; Su-Su Tang^a ; Mei Hu^a ; Yan Long^a ; Hong-Bin Sun^a ; Ling-Yi Kong^a ; Hao Hong^a ; ^{honghao@cpu.edu.cn}
• 关键词：Cysteinyl leukotrienes receptor 1 ; Memory ; Neuroinflammation ; Pranlukast ; Stereotaxic injection ; STZ ICV
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2017
• 出版时间：6 February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：19-30
• 全文大小：1798 K
• 卷排序：73

文摘

STZ (ICV) microinjection induces memory deficit in mice through hippocampal CysLT1R upregulation. shRNA-mediated knockdown of CysLT1R reverses STZ-induced memory impairment. Pranlukast, a CysLT1R antagonist, reverses STZ-induced neuroinflammation by blocking NF-κB signaling.