Expression of rapeseed MAPKKK4 induced ROS accumulation and cell death in leaves.
Cell death induced by MAPKKK4 is associated with membrane lipid peroxidation and DNA fragmentation.
MAPKKK4 interacts with MKK5 and MPK3.
MAPKKK4-induced ROS accumulation and cell death require downstream WIPK and SIPK.
MAPKKK4 is a novel MAPKKK modulating ROS accumulation and cell death.