Lipopolysaccharides-stimulated macrophage products enhance Withaferin A-induced apoptosis via activation of caspases and inhibition of NF-κB pathway in human cancer cells

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• 作者：Liang Piao^a ; ¹ ; Zhao Canguo^a ; ¹ ; Lu Wenjie^a ; Cheng Xiaoli^b ; Shi Wenli^c ; Lu Li^a ; ^d ; ^{2000990017@gzhmu.edu.cn} ; ^{925295339@qq.com}
• 关键词：Macrophage ; Withaferin A ; Apoptosis ; NF-κB pathway
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：92-101
• 全文大小：2940 K
• 卷排序：81

文摘

LPS-stimulated macrophage products (LSMP) may enhance WA-induced apoptosis. WA plus LSMP co-treatment can decrease the expression of pro-caspases-8, pro-caspases-9, pro-caspase-3 and anti-apoptotic proteins (XIAP and cIAP) and increase the cleavage of PARP. WA plus LSMP co-treatment significantly decrease the nuclear NF-κB-p65 levels. Our findings will provide an effective strategy that targets macrophages to enhance the antitumor efficacy of cytotoxic chemotherapy.