Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis

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• 作者：Pei-Feng Liu ; Wenyuan Shi ; Wenhong Zhu ; Jeffery W. Smith ; Shie-Liang Hsieh ; Richard L. Gallo ; Chun-Ming Huang
• 关键词：Co-aggregation ; Fusobacterium nucleatum ; FomA ; Porphyromonas gingivalis ; Vaccine ; Abscesses ; Halitosis
• 刊名：Vaccine
• 出版年：2010
• 出版时间：26 April 2010
• 年：2010
• 卷：28
• 期：19
• 页码：3496-3505
• 全文大小：1110 K

文摘

The mechanical therapy with multiple doses of antibiotics is one of modalities for treatment of periodontal diseases. However, treatments using multiple doses of antibiotics carry risks of generating resistant strains and misbalancing the resident body flora. We present an approach via immunization targeting an outer membrane protein FomA of Fusobacterium nucleatum (F. nucleatum), a central bridging organism in the architecture of oral biofilms. Neutralization of FomA considerably abrogated the enhancement of bacterial co-aggregation, biofilms and production of volatile sulfur compounds mediated by an inter-species interaction of F. nucleatum with Porphyromonas gingivalis (P. gingivalis). Vaccination targeting FomA also conferred a protective effect against co-infection-induced gum inflammation. Here, we advance a novel infectious mechanism by which F. nucleatum co-opts P. gingivalis to exacerbate gum infections. FomA is highlighted as a potential target for development of new therapeutics against periodontal infection and halitosis in humans.