Elevated glucose levels impair the WNT/β-catenin pathway via the activation of the hexosamine biosynthesis pathway in endometrial cancer
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- 作者：Fuxing Zhoua ; Junwei Huob ; Yu Liua ; Haixia Liua ; Gaowei Liua ; Ying Chenc ; Biliang Chena ; chenbiliang1962@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Elevated glucose levels ; WNT/β-catenin ; O-GlcNAc ; Endometrial cancer
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：19-25
- 全文大小：1813 K
文摘
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AN3CA and HEC-1-B cells showed high β-catenin expression under elevated glucose levels.
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Both cell lines also exhibited an increase in O-GlcNAcylation levels.
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β-catenin expression increases via activation of HBP in both cell lines.
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Glucose-induced β-catenin elevation triggers the transcription of target genes.