Marc-145 cell lines stable expression PRRSV GP5 or truncated GP5 were constructed.
GP5螖97-119 expression in Marc-145 cell induced cell cycle arrest at G2/M phase.
Expression of GP5 and truncated GP5 could not induce Marc-145 cells apoptosis.
PRRSV replication in Marc-145-GP5螖84-96 was significantly inhibited.