Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium–DMSO complexes containing 2,2′-biimidazole

详细信息    查看全文

• 作者：Caiping Tan ; Sheng Hu ; Jie Liu ; Liangnian Ji
• 关键词：Ruthenium complexes ; 2 ; 2′ ; -Biimidazole ; Apoptosis ; Anti-metastatic ; CDK inhibitors
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：46
• 期：5
• 页码：1555-1563
• 全文大小：1245 K

文摘

Two new ruthenium complexes, trans,cis,cis-[RuCl₂(DMSO)₂(H₂biim)] (1) and mer-[RuCl₃(DMSO)(H₂biim)] (2) (DMSO = dimethyl sulfoxide and H₂biim = 2,2′-biimidazole), have been synthesized and fully characterized by single-crystal X-ray analysis. The less stable complex 2 is more cytotoxic against the four human cancer cell lines tested than 1. Further studies show that 1 and 2 exhibit cell growth inhibition by triggering G0/G1 cell cycle arrest and mitochondria-mediated apoptosis. Additionally, complex 2 exerts potent inhibitory effects on the adhesion and migration of human cancer cells comparable to that of NAMI-A ([ImH][trans-[RuCl₄(Im)(DMSO-S)], Im = imidazole). Target validation studies show that cyclin-dependent kinases (CDKs), other than DNA, are more likely to be targets of 1 and 2.