Neuroprotective effect of curcumin on hippocampal injury in 6-OHDA-induced Parkinson's disease rat

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• 作者：Jiaqing Yang^a ; Shilei Song^a ; Jian Li^a ; ^{lijian_hospital@163.com" class="auth_mail} ; Tao Liang^b
• 关键词：Curcumin ; Neural injury ; Hippocampi ; Neuroprotection
• 刊名：Pathology - Research and Practice
• 出版年：June 2014
• 年：2014
• 卷：210
• 期：6
• 页码：357-362
• 全文大小：1738 K

文摘

Clinically, Parkinson's disease (PD)-related neuronal lesions commonly occur. The purpose of this study is to investigate potential therapeutic effect of curcumin against hippocampal damage of 6-hydroxydopamine (6-OHDA)-PD rat model. These results showed that curcumin significantly increased the body weight of 6-OHDA-impaired rats (P < 0.01), and reversed the anhedonia in rats induced by 6-OHDA impairment (P < 0.01). Meanwhile, behavioral manifestations of curcumin-treated PD rats were effectively ameliorated as shown in open field test (P < 0.01). In addition, curcumin increased the contents of monoaminergic neurotransmitters (P < 0.01), such as dopamine (DA) and norepinephrine (NE), in hippocampal homogenate through high performance liquid chromatography (HPLC) assay. Curcumin effectively alleviated the 6-OHDA-induced hippocampal damage as observed in hematoxylin–eosin (H&E) staining. Furthermore, curcumin obviously up-regulated hippocampal brain derived neurotrophic factor (BDNF), TrkB, phosphatidylinositide 3-kinases (PI3K) protein expressions, respectively as shown in Western blot analysis. These findings demonstrated that curcumin mediated the neuroprotection against 6-OHDA-induced hippocampus neurons in rats, which the underlying mechanism is involved in activating BDNF/TrkB-dependent pathway for promoting neural regeneration of hippocampal tissue.