Antithrombotic Medication Use and Misuse Among Patients with Intracranial Hemorrhage: A 16-Year, Lebanese, Single-Center Experience

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• 作者：Elie Fahed¹ ; Jessica Ghauche² ; Ralph Rahme³ ; Nabil Okais¹ ; Elie Samaha¹ ; Georges Nohra¹ ; Tony Rizk¹ ; Joseph Maarrawi¹ ; Lina Menassa-Moussa² ; Ronald Moussa¹ ; ^{ronald_moussa@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Anticoagulant ; Antiplatelet ; Antithrombotic ; Intracerebral hemorrhage ; Intracranial hemorrhage ; Subarachnoid hemorrhage
• 刊名：World Neurosurgery
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：95
• 期：Complete
• 页码：143-147
• 全文大小：2142 K

文摘

The use of antithrombotic medication (ATM) frequently is reported in patients with intracranial hemorrhage (ICH) and is associated with increased mortality. Unfortunately, ATMs sometimes are prescribed and/or used inappropriately. We sought to determine the rate of ATM misprescription/misuse among patients with ICH in a single-center retrospective study.

Methods

All patients admitted with ATM-related ICH in 1998−2014 were included. Charts were reviewed and demographic, clinical, and radiologic variables were recorded. The type of ATM, dose, and duration of treatment were analyzed critically. The adequacy of ATM prescription/use was assessed in light of the recommendations and guidelines of the American Heart Association, American Stroke Association, and French National Authority for Health, in effect at the time of admission.

Results

A total of 106 patients with mean age 68 years were identified. Aspirin (53.8%) was the most commonly used drug, followed by oral anticoagulants (31.1%) and clopidogrel (22.6%). In only 80 patients (75.5%), the use of ATM was in line with contemporary guidelines. In the remaining 26 (24.5%), the use of ATMs was inappropriate, including bad drug combination, wrong dose, poor indication, wrong drug class, and/or incorrect treatment duration.

Conclusions

In this Lebanese cohort of patients with ICH, the 24.5% rate of ATM misprescription and/or misuse is highly alarming and the origin of this problem is likely multifactorial. Immediate measures should be undertaken, and efforts should be focused on regaining tight control of ATM prescription and fulfillment, ensuring good patient education, and offering more vigilant oversight on physician licensure.