Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch
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- 作者：Daniel T. MacLeod1 ; 10 ; 12 ; Nancy M. Choi1 ; 10 ; 12 ; Bryan Briney1 ; 2 ; 4 ; Fernando Garces1 ; 3 ; 4 ; Lorena S. Ver1 ; 10 ; Elise Landais1 ; 10 ; Ben Murrell5 ; Terri Wrin6 ; William Kilembe7 ; Chi-Hui Liang2 ; Alejandra Ramos1 ; 10 ; Chaoran B. Bian1 ; 10 ; Lalinda Wickramasinghe1 ; 10 ; Leopold Kong1 ; 3 ; 4 ; Kemal Eren5 ; Chung-Yi Wu8 ; Chi-Huey Wong8 ; The IAVI Protocol C Investigators & The IAVI African HIV Research Network10 ; Matt A. Price ; Jill Gilmour ; Pat Fast ; Anatoli Kamali ; Eduard J. Sanders ; Omu Anzala ; Susan Allen ; Eric Hunter ; Etienne Karita ; William Kilembe ; Shabir Lakhi ; Mubiana Inambao ; Vinodh Edward ; Linda-Gail Bekker
- 刊名：Immunity
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：44
- 期：5
- 页码：1215-1226
- 全文大小：2204 K
文摘
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N332-site Abs with low somatic mutation and no indels achieve broad neutralization
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N332-bnAb lineage diversifies early into multiple limbs
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Independent maturation of lineage limbs leads to diverse N332-site bnAb recognition
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Abs to the N332 site show CDRH3s with extended “dagger”-like shapes