A liquid chromatography/mass spectrometry method for the evaluation of intestinal permeability
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- 作者：Alfonso M. Lostia ; Luana Lionetto ; Luigi Principessa ; Melania Evangelisti ; Amelia Gamba ; Maria Pia Villa ; Maurizio Simmaco
- 关键词：Abdominal recurrent pain ; Intestinal permeability ; Lactulose ; Mannitol ; Multiple-reaction monitoring ; LC– ; MS/MS
- 刊名：Clinical Biochemistry
- 出版年：2008
- 出版时间：July 2008
- 年：2008
- 卷：41
- 期：10-11
- 页码：887-892
- 全文大小：381 K
文摘
Lactulose to mannitol ratio (L/M) in urine is used as a non invasive assay to measure intestinal permeability. We describe here a rapid, specific and sensitive LC–MS/MS method for the measurement of these compounds in urine of children affected by abdominal recurrent pain (ARP).