- 作者：Lisa Nelson ; drlisanelson@hotmail.com ; Kenneth J. Stewart
- 关键词：HIV Lipodystrophy ; Fillers ; 3-D imaging ; Psychological outcomes
- 刊名：Journal of Plastic, Reconstructive Aesthetic Surgery
- 出版年：2012
- 出版时间：April, 2012
- 年：2012
- 卷：65
- 期：4
- 页码：439-447
- 全文大小：767 K
Summary
HIV lipoatrophy is a stigmatizing condition associated with significant psychological morbidity. The aim of this study was to evaluate change in facial volume and psychological morbidity following treatment with autologous fat, Sculptra? and Bio-alcamid?.Methods
HIV LD patients were treated based on a clinical assessment in a prospective, observational study. 3-D images were obtained pre-operatively then at 2, 6 and 12 months post-operatively using the DI3D system. Volume changes were measured using DI3D software. The DAS-24 and HADS were used to assess psychological morbidity at similar time intervals.
Results
Forty-eight patients with HIV LD were treated: 16 patients had Bio-alcamid?, 20 patients received Sculptra? and 12 patients underwent fat transfer. The mean injected volume of Bio-alcamid? was 25.5 cc which was comparable to the measured volume change at follow-up. The mean injected volume of fat was 20.1 cc, which did not differ from the measured volumes at 2 months. There was a mean reduction in measured volume change to11.2 cc at 6 months and 10 cc at 12 months.
For Sculptra?, the mean volume change compared to baseline was 8.7 cc at 2 months, increasing to 12.6 cc at 6 months and 12.3 cc at 12 months.
ANOVA tests demonstrated no difference in psychological outcomes between groups. There was a significant improvement in DAS-24 scores compared to baseline for all 3 groups. No correlation between change in facial volume and psychological measures was demonstrated.
Conclusions
Change in 3-D measured facial volume for all 3 groups was seen. Treatment was associated with improved body image perception.