- 作者：Fionn Chen ; Alastair Carruthers ; Shannon Humphrey ; Jean Carruthers
- 关键词：facial lipoatrophy ; HIV-associated lipoatrophy ; liquid injectable silicone ; permanent soft tissue filler ; silicone oil
- 刊名：Journal of the American Academy of Dermatology
- 出版年：2013
- 出版时间：September, 2013
- 年：2013
- 卷：69
- 期：3
- 页码：431-437
- 全文大小：981 K
Background
Facial lipoatrophy (FLA) is associated with HIV infection and is part of the lipodystrophy syndrome. Temporary filler treatments do not meet the need of the patient, as there is a lack of permanence, and excessive cost.Objective
We sought to evaluate the safety and efficacy of a highly purified medical-grade 1000-cst liquid injectable silicone in the treatment of HIV-associated FLA using the serial microdroplet injection technique.
Methods
Twenty patients with HIV-associated lipoatrophy were treated with liquid injectable silicone with a maximum of 6 treatment sessions (2.0 mL each session maximum). Patients were evaluated at 9-, 12-, and 18-month follow-up sessions. Safety, efficacy, injection volumes, and patient satisfaction were evaluated.
Results
No persistent adverse effects were reported throughout the study. Most of the patients achieved complete correction of their HIV-associated FLA after 6 treatments and maintained this correction to the 18-month follow-up.
Limitations
This is a noncomparative, nonblinded study. Study patient population size is small.
Conclusion
Given our small sample size of 20 patients, our results suggest that, if administered correctly, liquid injectable silicone is potentially a safe, effective, and natural-feeling treatment option for HIV-associated FLA. Larger studies may be needed to confirm safety, efficacy, and permanence.