CD14+ CD16++ monocytes are increased in patients with NMO and are selectively suppressed by glucocorticoids therapy
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- 作者：Qiuming Zeng ; Xiaohua Dong ; Chunyun Ruan ; Bo Hu ; Yuebei Luo ; Zhaohui Luo ; Liqun Xu ; Hao Zhou ; Runqi Wang ; Huan Yang ; yangh69@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuromyelitis optica ; Glucocorticoids ; Monocyte subsets ; Interleukin-1beta ; Tumor necrosis factor-alpha ; Flow cytometry
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：300
- 期：Complete
- 页码：1-8
- 全文大小：814 K
文摘
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The level of nonclassical monocytes was significantly increased and selectively suppressed by GC in patients with NMO.
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Circulating nonclassical monocytes, the levels of IL-1β and TNF-α are all correlated with NMO disability severity.
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Nonclassical monocytes may be a potential disease biomarker and a therapeutic target in the active phase of NMO.