Relationship between −592A/C polymorphism of interleukin-10 (IL-10) gene and risk of early carotid atherosclerosis

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• 作者：Gaoqiang Xie ; Phyo K. Myint ; Liancheng Zhao ; Ying Li ; Hao Wang ; Lirong Liang ; Yangfeng Wu
• 关键词：− ; 592A/C polymorphism ; Highly sensitive C-reactive protein ; Carotid atherosclerosis ; Gene– ; risk factor interaction ; Interleukin-10
• 刊名：International Journal of Cardiology
• 出版年：2010
• 出版时间：6 August 2010
• 年：2010
• 卷：143
• 期：1
• 页码：102-104
• 全文大小：66 K

文摘

In a community-based study of 1295 Chinese men and women free of myocardial infarction and stroke we found that interleukin-10 (IL-10) −592C/C genotype was significantly associated with decreased risk of early carotid atherosclerosis compared to −592 A/A genotype. This observed association was significantly modified by known atherogenic risk factors namely smoking and obesity. In people with normal cholesterol (< 200 mg/L), −592 C/C genotype was also associated with lower levels of highly-sensitive C-reactive protein. Our findings generate an interesting hypothesis that the IL-10 −592C/C genotype may exert its protection against early atherosclerosis through anti-inflammatory pathways. Our results also confirm that gene–risk factor interaction plays an important role in pathogenesis of early atherosclerosis.