Prevalence and severity of dry eye in candidates for laser in situ keratomileusis for myopia in Russia

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• 作者：Dmitry Yurevich Maychuk ; MD ; PhD ; DMSc ; ^{maychuk@mail.ru" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; on behalf of the Dry Eye Prevalence Study GroupSvetlana Anisimova ; MD ; PhD ; DMSc ; Svetlana Kapkova ; MD ; PhD ; Andrei Kachanov ; MD ; PhD ; Sergei Korotkikh ; MD ; PhD ; DMSc. ; Alexei Seleznev ; MD ; PhD ; Sergei Sakhnov ; MD ; PhD ; DMSc. ; Elena Leonova ; MD ; PhD ; DMSc. ; Sergei Krylov ; MD ; PhD
• 刊名：Journal of Cataract & Refractive Surgery
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：42
• 期：3
• 页码：427-434
• 全文大小：452 K

文摘

To assess the prevalence and severity of dry-eye disease in patients with myopia being evaluated for laser in situ keratomileusis.

Setting

Nine ophthalmology centers in Russia.

Design

Prospective noninterventional cross-sectional study.

Methods

The assessments included the Schirmer I test, tear breakup time (TBUT), lissamine green and fluorescein staining (Oxford grading scheme), Ocular Surface Disease Index (OSDI) questionnaire, and Dry Eye Workshop (DEWS) dry-eye severity grading.

Results

The study comprised 400 patients with myopia (mean age 29.7 years); 145 (36.2%) wore contact lenses, and 81 (20.2%) used topical dry-eye medication. The mean Schirmer test score was 15.2 mm; 36.5% of patients had evidence of tear-volume deficiency (Schirmer score ≤10 mm). The mean TBUT was 11.7 seconds; 10.1% of patients had tear-film instability (TBUT <5 seconds). Conjunctival (lissamine green) staining intensity was categorized as minimal or greater (grade ≥1) in 62.3% of patients and mild or greater (grade ≥2) in 22.8% of patients. The mean OSDI score was 20.4, indicating mild ocular disability. Dry-eye severity (DEWS grading) was mild/episodic in 66.2%, moderate in 29.5%, and severe in 4.3% of patients. No clear correlation was evident between the Schirmer/TBUT scores and the lissamine green/OSDI scores.

Conclusions

The prevalence of dry eye in this population was estimated at approximately 10% to 40% (based on clinical signs) and 40% to 55% (based on symptoms); dry-eye severity was predominantly mild/episodic. The proportion of patients requiring dry-eye therapy (based on OSDI and DEWS severity findings) was almost 2 times higher than the proportion receiving treatment.

Financial Disclosure

Dr. Maychuk has received research funding from Allergan CIS SARL.