In situ derivatization-ultrasound-assisted dispersive liquid-liquid microextraction for the determination of neurotransmitters in Parkinson’s rat brain microdialysates by ultra high performance liquid chromatography-tandem mass spectrometry
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- 作者：Yongrui Hea ; Xian-En Zhaoa ; xianenzhao@163.com" class="auth_mail" title="E-mail the corresponding author ; Shuyun Zhua ; Na Weia ; Jing Sunc ; Yubi Zhouc ; Shu Liub ; Zhiqiang Liub ; liuzq@ciac.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Guang Chena ; Yourui Suoc ; Jinmao Youa ; c ; jmyou6304@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：In situ derivatization ; Ultrasound-assisted dispersive liquid&ndash ; liquid microextraction ; In vivo microdialysis ; Neurotransmitters ; Ultra high performance liquid chromatography-tandem mass spectrometry ; Traditional chinese medicine
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：1458
- 期：Complete
- 页码：70-81
- 全文大小：3532 K
文摘
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In situ derivatization-UADLLME was firstly reported for NTs in rat brain microdialysates.
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Lissamine rhodamine B sulfonyl chloride was firstly used as derivatization reagent.
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The method was simple, rapid, green, efficient, sensitive and low matrix effect.
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This method was successfully applied for Parkinson’s rat brain microdialysates.