LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56

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• 作者：Abhinav K. Jain¹ ; ² ; ³ ; ^{ajain@mdanderson.org} ; Yuanxin Xi⁴ ; Ryan McCarthy¹ ; ² ; ³ ; Kendra Allton¹ ; ² ; ³ ; Kadir C. Akdemir⁵ ; Lalit R. Patel¹ ; ⁸ ; Bruce Aronow⁶ ; Chunru Lin⁷ ; Wei Li⁴ ; Liuqing Yang⁷ ; Michelle C. Barton¹ ; ² ; ³ ; ⁸ ; ⁹ ; ^{mbarton@mdanderson.org}
• 关键词：p53 ; lncRNA ; SIRT6 ; hESC ; genome-wide ; pluripotency ; differentiation ; chromatin ; H3K56ac ; H3K9ac
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：64
• 期：5
• 页码：967-981
• 全文大小：5251 K
• 卷排序：64

文摘

p53 represses ESC-specific lncRNA, LncPRESS1, during human ESC differentiation LncPRESS1 controls a transcriptional network that favors pluripotency LncPRESS1 acts as a decoy to restrict SIRT6 activity at pluripotency gene promoters LncPRESS1 controls hESC fate by maintaining high H3K56/K9ac at pluripotency genes