Phthalate intake by infants calculated from biomonitoring data

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• 作者：Wolfgang V枚lkel ; M ; y Kiranoglu ; Ralph Schuster ; Hermann Fromme ; for the HBMnet
• 关键词：Infants ; Biomonitoring ; Phthalates ; Risk assessment ; Urinary excretion
• 刊名：Toxicology Letters
• 出版年：3 March, 2014
• 年：2014
• 卷：225
• 期：2
• 页码：222-229
• 全文大小：759 K

文摘

Urine samples (n = 207) of 47 infants between 1- and 5-month of age were quantitated for 12 metabolites of 7 phthalates and compared with samples collected from the mothers of the infants at different time points. Median and 95-percentile were lower for all metabolites in urine samples of infants compared to mothers. For di-2-ethylhexyl phthalate (DEHP) the 95-percentile daily intake was 23.3 渭g/kg b.w. for mothers and 5.4 渭g/kg b.w. for infants and for di-isobutyl phthalate (DiBP) 10.1 渭g/kg b.w. and 8.5 渭g/kg b.w. Some values exceeded the corresponding tolerable daily intake (TDI) for DiBP for infants and mothers and for DEHP and di-n-butyl phthalate (DnBP) only for mothers. Both, infants and mothers are able to efficiently form phase II metabolites but infants with a slightly lower degree. Therefore, a distinguished risk assessment with respect to the formed toxic metabolites of phthalates would be necessary in combination with a reduction of the most toxic phthalates.