Systematic development of solid self-nanoemulsifying oily formulations (S-SNEOFs) for enhancing the oral bioavailability and intestinal lymphatic uptake of lopinavir
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- 作者：Babita Garga ; O.P. Katarea ; Sarwar Bega ; Shikha Lohanb ; Bhupinder Singha ; b ; bsbhoop@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; bsbhoop@pu.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chylomicron flow block model ; Bioavailability ; Quality by design (QbD) ; SNEDDS ; In situ single pass intestinal perfusion ; Biodistribution
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：611-622
- 全文大小：3405 K
文摘
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Novel system for the BCS class II drug molecules with poor oral bioavailability.
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Systematic optimized Novel S-SNEOFs for enhanced bioavailability of lopinavir.
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Safe delivery system of lopinavir for the effective accessibility to the GALT.
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Efficacious therapy for the eradication of the HIV loads in sanctuary sites.