Random lopinavir concentrations predict resistance on lopinavir-based antiretroviral therapy
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- 作者：Richard Courta ; richard.court@uct.ac.za" class="auth_mail" title="E-mail the corresponding author ; Michelle Gordonb ; Karen Cohena ; Annemie Stewartc ; Bernadett Gosnelld ; Lubbe Wiesnera ; Gary Maartensa
- 关键词：HIV ; Lopinavir pharmacokinetics ; Protease inhibitor ; Second-line antiretroviral therapy ; Antiretroviral resistance ; Therapeutic drug monitoring
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：48
- 期：2
- 页码：158-162
- 全文大小：333 K
文摘
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Most patients fail second-line antiretroviral therapy (ART) owing to poor adherence rather than resistance.
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Predictors of protease inhibitor (PI) resistance in patients with second-line virological failure (VF) are needed.
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We found random lopinavir (LPV) concentrations to be the strongest predictor of PI resistance.
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Other factors associated with PI resistance were male sex and duration on LPV.
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Genotype antiretroviral resistance testing could be limited to patients in VF with random LPV concentrations ≥1 µg/mL.