Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells
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- 作者：Hui Yina ; Huaxin Zhoub ; Yi Kanga ; Xiaoju Zhanga ; Xiaoxian Duanb ; Ridab Alnabhanb ; Shuang Liangb ; David A. Scottb ; Richard J. Lamontb ; Jia Shanga ; shangjia666@126.com" class="auth_mail" title="E-mail the corresponding author ; Huizhi Wangb ; hhwang01@louisville.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Syk ; Toll-like receptor 4 ; Interferon-β ; IL-10 ; PI3K ; GSK3β
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1860
- 期：3
- 页码：588-598
- 全文大小：1739 K
文摘
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Syk deficiency enhances the production of IFNβ and IL-10 through promoting the activity of PI3K–Akt–GSK3β signaling.
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Syk deficiency decreases the production of pro-inflammatory cytokines through suppressing the activity of NF-κB.
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Syk is a novel innate regulator and potential intervention target for the control of inflammatory responses.